Antiplasmodial, Trypanocidal, and Genotoxicity <i>In Vitro</i> Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives

Antiplasmodial, Trypanocidal, and Genotoxicity <i>In Vitro</i> Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives

Background: Statins present a plethora of pleiotropic effects including anti-inflammatory and antimicrobial responses. A,α-difluorophenylacetamides, analogs of diclofenac, are potent pre-clinical anti-inflammatory non-steroidal drugs. Molecular hybridization based on the combination of pharmacophori...

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Bibliografski detalji
Glavni autori: Carlos Fernando Araujo-Lima, Rita de Cassia Castro Carvalho, Sandra Loureiro Rosario, Debora Inacio Leite, Anna Caroline Campos Aguiar, Lizandra Vitoria de Souza Santos, Julianna Siciliano de Araujo, Kelly Salomão, Carlos Roland Kaiser, Antoniana Ursine Krettli, Monica Macedo Bastos, Claudia Alessandra Fortes Aiub, Maria de Nazaré Correia Soeiro, Nubia Boechat, Israel Felzenszwalb
Format: Članak
Jezik:English
Izdano: MDPI AG 2023-05-01
Serija:Pharmaceuticals
Teme:
phenylacetamides
atorvastatin
hybrid compounds
chemical synthesis
drug development
antiparasitic activity
Online pristup:https://www.mdpi.com/1424-8247/16/6/782

Internet

https://www.mdpi.com/1424-8247/16/6/782

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