Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System

Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System

The spike protein (SP) of SARS-CoV-2 is an important target for COVID-19 therapeutics and vaccines as it binds to the ACE2 receptor and enables viral infection. Rapid production and functional characterization of properly folded SP is of the utmost importance for studying the immunogenicity and rece...

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Bibliographic Details
Main Authors: Yutaro Yamaoka, Sundararaj Stanleyraj Jeremiah, Rikako Funabashi, Kei Miyakawa, Takeshi Morita, Yusaku Mihana, Hideaki Kato, Akihide Ryo
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
COVID-19
SARS-CoV-2
RBD
disulfide bond
cell-free protein synthesis
drug screening
Online Access:https://www.mdpi.com/1999-4915/14/7/1461

Internet

https://www.mdpi.com/1999-4915/14/7/1461

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