GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments
Many therapeutic proteins are small in size and are rapidly cleared from circulation. Consequently, half-life extension strategies have emerged to improve pharmacokinetic properties, including fusion or binding to long-lasting serum proteins, chemical modifications with hydrophilic polymers such as...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-05-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/10/3272 |