Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata.

Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds has been studied, nothing is known about the genetics of their biosynthesis. O...

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Bibliographic Details
Main Authors: Debjani Saha, Ramona Fetzner, Britta Burkhardt, Joachim Podlech, Manfred Metzler, Ha Dang, Christopher Lawrence, Reinhard Fischer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3391263?pdf=render