Zearalenone-Induced Interaction between PXR and Sp1 Increases Binding of Sp1 to a Promoter Site of the eNOS, Decreasing Its Transcription and NO Production in BAECs

Zearalenone-Induced Interaction between PXR and Sp1 Increases Binding of Sp1 to a Promoter Site of the eNOS, Decreasing Its Transcription and NO Production in BAECs

Zearalenone (ZEN) is a non-steroidal mycotoxin that has various toxicological impacts on mammalian health. Here, we found that ZEN significantly affected the production of nitric oxide (NO) and the expression of endothelial NO synthase (eNOS) of bovine aortic endothelial cells (BAECs). A promoter an...

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Bibliographic Details
Main Authors: Hyeon-Ju Lee, Jung-Hyun Park, Se-Young Oh, Du-Hyong Cho, Suji Kim, Inho Jo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Toxins
Subjects:
zearalenone
eNOS
PXR
Sp1
NO
Online Access:https://www.mdpi.com/2072-6651/12/6/421

Internet

https://www.mdpi.com/2072-6651/12/6/421

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