Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice

Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice

Lysyl oxidase-like 1 encoded by the LOXL1 gene is a member of the lysyl oxidase family of enzymes that are important in the maintenance of extracellular matrix (ECM)-rich tissue. LOXL1 is important for proper elastic fiber formation and mice lacking LOXL1 (Loxl1−/−) exhibit systemic elastic fiber di...

Full description

Bibliographic Details
Main Authors: Lauren K. Wareham, John Kuchtey, Hang-Jing Wu, Evan Krystofiak, Yusheng Wu, Cynthia A. Reinhart-King, Rachel W. Kuchtey
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Matrix Biology Plus
Subjects:
Lysyl oxidase-like 1
Exfoliation glaucoma
Peripapillary sclera
Extracellular matrix
Transmission electron microscopy
Atomic force microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028522000205

Internet

http://www.sciencedirect.com/science/article/pii/S2590028522000205

Similar Items