Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells

Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells

Abstract Background Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin and VEGF type 2 receptor (VEGFR2) in VEGF-induced angiogenesis. DisBa-...

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Bibliographic Details
Main Authors: Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei, Heloisa S. Selistre-de-Araujo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cell Communication and Signaling
Subjects:
αvβ3 integrin
VEGFR2
Cross-talk
Disintegrin
DisBa-01
Extracellular matrix
Online Access:http://link.springer.com/article/10.1186/s12964-019-0339-1

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http://link.springer.com/article/10.1186/s12964-019-0339-1

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