Whole-transcriptome sequencing–based concomitant detection of viral and human genetic determinants of cutaneous lesions

Whole-transcriptome sequencing–based concomitant detection of viral and human genetic determinants of cutaneous lesions

Severe viral infections of the skin can occur in patients with inborn errors of immunity (IEI). We report an all-in-one whole-transcriptome sequencing–based method by RNA-Seq on a single skin biopsy for concomitantly identifying the cutaneous virome and the underlying IEI. Skin biopsies were obtaine...

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Bibliographic Details
Main Authors: Amir Hossein Saeidian, Leila Youssefian, Charles Y. Huang, Fahimeh Palizban, Mahtab Naji, Zahra Saffarian, Hamidreza Mahmoudi, Azadeh Goodarzi, Soheila Sotoudeh, Fatemeh Vahidnezhad, Maliheh Amani, Narjes Tavakoli, Ali Ajami, Samaneh Mozafarpoor, Mehrdad Teimoorian, Saeed Dorgaleleh, Sima Shokri, Mohammad Shenagari, Nima Abedi, Sirous Zeinali, Paolo Fortina, Vivien Béziat, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto, Hassan Vahidnezhad
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-04-01
Series:JCI Insight
Subjects:
Genetics
Infectious disease
Online Access:https://doi.org/10.1172/jci.insight.156021

Internet

https://doi.org/10.1172/jci.insight.156021

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