Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Metastatic uveal melanoma (MUM) is characterized by poor patient survival. Unfortunately, current treatment options demonstrate limited benefits. In this study, we evaluate the efficacy of ACY-1215, a histone deacetylase inhibitor (HDACi), to attenuate growth of primary ocular UM cell lines and, in...

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Bibliographic Details
Main Authors: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto, Kayleigh Slater, Simone Marcone, Josep M. Piulats, Ronald William Watson, Desmond J. Tobin, Lasse D. Jensen, Breandán N. Kennedy
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
metastatic uveal melanoma
HDAC inhibitor
ACY-1215
MITF
p-ERK
ML329
Online Access:https://www.mdpi.com/2072-6694/14/3/782

Internet

https://www.mdpi.com/2072-6694/14/3/782

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