Exosomal miR-132-3p from mesenchymal stromal cells improves synaptic dysfunction and cognitive decline in vascular dementia

Exosomal miR-132-3p from mesenchymal stromal cells improves synaptic dysfunction and cognitive decline in vascular dementia

Abstract Background/aims Vascular dementia (VD) results in cognition and memory deficit. Exosomes and their carried microRNAs (miRs) contribute to the neuroprotective effects of mesenchymal stromal cells, and miR-132-3p plays a key role in neuron plasticity. Here, we investigated the role and underl...

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Bibliographic Details
Main Authors: Xiaotang Ma, Yan Wang, Yumeng Shi, Suqing Li, Jinhua Liu, Xiangyong Li, Wangtao Zhong, Qunwen Pan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Vascular dementia
Mesenchymal stromal cells
Exosomes
miR-132-3p
Synaptic plasticity
Online Access:https://doi.org/10.1186/s13287-022-02995-w

Internet

https://doi.org/10.1186/s13287-022-02995-w

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