Hepatic FOXA3 overexpression prevents Western diet–induced obesity and MASH through TGR5

Forkhead transcription factor 3 (FOXA3) has been shown to regulate metabolism and development. Hepatic FOXA3 is reduced in obesity and fatty liver disease. However, the role of hepatic FOXA3 in regulating obesity or steatohepatitis remains to be investigated. In this work, C57BL/6 mice were i.v. inj...

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Bibliographic Details
Main Authors: Raja Gopoju, Jiayou Wang, Xiaoli Pan, Shuwei Hu, Li Lin, Alyssa Clark, Yanyong Xu, Liya Yin, Xinwen Wang, Yanqiao Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524000324