A phase I open-label clinical trial to study drug-drug interactions of Dorzagliatin and Sitagliptin in patients with type 2 diabetes and obesity

Dorzagliatin, which acts on the glucose sensor glucokinase, is a new class of anti-diabetic medicine. Here the authors report that in a phase I open-label trial co-administration of dorzagliatin and sitagliptin (a different class of anti-diabetic medicine) does not significantly change the pharmacok...

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Bibliographic Details
Main Authors: Li Chen, Jiayi Zhang, Yu Sun, Yu Zhao, Xiang Liu, Zhiyin Fang, Lingge Feng, Bin He, Quanfei Zou, Gregory J. Tracey
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36946-7