Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells

Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells

Abstract Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have been described as macrophage like, or foam cells. VSMC foam cells make u...

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Bibliographic Details
Main Authors: Pamela Swiatlowska, William Tipping, Emilie Marhuenda, Paolo Severi, Vitalay Fomin, Zhisheng Yang, Qingzhong Xiao, Duncan Graham, Cathy Shanahan, Thomas Iskratsch
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
atherosclerosis
foam cells
mechanosensing
pressure sensing
vascular smooth muscle cells
Online Access:https://doi.org/10.1002/advs.202308686

Internet

https://doi.org/10.1002/advs.202308686

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