Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury

Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is compromised by potential teratogenicit...

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Bibliographic Details
Main Authors: Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Biomedical Science
Subjects:
Neuroinflammation
Thalidomide
Cereblon
Immunomodulatory imide drugs (IMiDs)
Neurodegeneration
Microglia
Online Access:https://doi.org/10.1186/s12929-023-00907-5

Internet

https://doi.org/10.1186/s12929-023-00907-5

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