Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (<i>S</i>)-Betaxolol
The β-blocker (<i>S</i>)-betaxolol has been synthesized in 99% enantiomeric excess (<i>ee</i>) from the commercially available precursor 4-(2-hydroxyethyl)phenol. The racemic chlorohydrin 1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol was esterified with vinyl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Catalysts |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4344/12/12/1645 |