A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses.

A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses.

Development of effective vaccines to prevent influenza, particularly highly pathogenic avian influenza (HPAI) caused by influenza A virus (IAV) subtype H5N1, is a challenging goal. In this study, we designed and constructed two recombinant influenza vaccine candidates by fusing hemagglutinin 1 (HA1)...

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Bibliographic Details
Main Authors: Lanying Du, Virtual Ho-Chuen Leung, Xiujuan Zhang, Jie Zhou, Min Chen, Wu He, Hai-Ying Zhang, Chris C S Chan, Vincent Kwok-Man Poon, Guangyu Zhao, Shihui Sun, Lifeng Cai, Yusen Zhou, Bo-Jian Zheng, Shibo Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3029370?pdf=render

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http://europepmc.org/articles/PMC3029370?pdf=render

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