A Recombinase Polymerase Amplification-Coupled Cas12a Mutant-Based Module for Efficient Detection of Streptomycin-Resistant Mutations in Mycobacterium tuberculosis

A Recombinase Polymerase Amplification-Coupled Cas12a Mutant-Based Module for Efficient Detection of Streptomycin-Resistant Mutations in Mycobacterium tuberculosis

Drug-resistant tuberculosis (TB) is a serious public health problem and threat to global TB prevention and control. Streptomycin (STR) is the earliest and classical anti-TB drug, and it is the earliest drug that generated resistance to anti-TB treatment, which limits its use in treating TB and imped...

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Bibliographic Details
Main Authors: Peng Liu, Xinjie Wang, Juan Liang, Qian Dong, Jinping Zhang, Dongxin Liu, Shuai Wang, Jing Bi, Wenqi Liu, Zhaoqin Wang, Liang Chen, Lei Liu, Xingxu Huang, Guoliang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Microbiology
Subjects:
streptomycin
drug resistance
tuberculosis
CRiSPR/Cas
recombinase polymerase amplification
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.796916/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.796916/full

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