Minibody-Based and scFv-Based Antibody Fragment-Drug Conjugates Selectively Eliminate GD2-Positive Tumor Cells

Minibody-Based and scFv-Based Antibody Fragment-Drug Conjugates Selectively Eliminate GD2-Positive Tumor Cells

Ganglioside GD2 is a well-established target expressed on multiple solid tumors, many of which are characterized by low treatment efficiency. Antibody-drug conjugates (ADCs) have demonstrated marked success in a number of solid tumors, and GD2-directed drug conjugates may also hold strong therapeuti...

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Bibliographic Details
Main Authors: Daniel V. Kalinovsky, Irina V. Kholodenko, Alexey V. Kibardin, Igor I. Doronin, Elena V. Svirshchevskaya, Dmitriy Y. Ryazantsev, Maria V. Konovalova, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
antibody fragments
scFv fragments
minibodies
antibody-drug conjugates
ganglioside GD2
immunotherapy
Online Access:https://www.mdpi.com/1422-0067/24/2/1239

Internet

https://www.mdpi.com/1422-0067/24/2/1239

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