A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims to characterize the impact of Mandarin fish r...

Full description

Bibliographic Details
Main Authors: Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Molecular Metabolism
Subjects:
Viral insulin/IGF-1 like peptides (VILPs)
IGF-1
Insulin
IGF1 receptor
IGF1 receptor inhibition
Biased signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001977

Internet

http://www.sciencedirect.com/science/article/pii/S2212877823001977

Similar Items