A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

Abstract Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to trauma, aging, or dystrophies and impairs muscle func...

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Bibliographic Details
Main Authors: Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perié, Jean Lacau St‐Guily, Aurélien Corneau, Gillian Butler‐Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Human
FAPs
Skeletal muscle
Pharyngeal muscle
Fibrosis
ECM
Online Access:https://doi.org/10.1002/jcsm.12974

Internet

https://doi.org/10.1002/jcsm.12974

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