A multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein

Abstract Identification of a protein minimal fragment amenable to crystallisation can be time- and labour intensive especially if large amounts are required and the protein has a complex fold and functionally important post-translational modifications. In addition, a lack of homologues and structura...

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Bibliographic Details
Main Authors: Hagen Sülzen, Jitka Votrubova, Arun Dhillon, Sebastian Zoll
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16958-x