Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late Toxicity After Radiotherapy and Low Radiation-Induced Lymphocyte Apoptosis

Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late Toxicity After Radiotherapy and Low Radiation-Induced Lymphocyte Apoptosis

BackgroundRadiation-induced late effects are a common cause of morbidity among cancer survivors. The biomarker with the best evidence as a predictive test of late reactions is the radiation-induced lymphocyte apoptosis (RILA) assay. We aimed to investigate the molecular basis underlying the distinct...

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Bibliographic Details
Main Authors: Ester Aguado-Flor, María J. Fuentes-Raspall, Ricardo Gonzalo, Carmen Alonso, Teresa Ramón y Cajal, David Fisas, Alejandro Seoane, Álex Sánchez-Pla, Jordi Giralt, Orland Díez, Sara Gutiérrez-Enríquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
radiotherapy—adverse effects
radiation-induced lymphocyte apoptosis (RILA)
gene set enrichment analysis (GSEA)
late skin toxicity
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.825703/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.825703/full

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