Establishment of multi-stage intravenous self-administration paradigms in mice

Abstract Genetically tractable animal models provide needed strategies to resolve the biological basis of drug addiction. Intravenous self-administration (IVSA) is the gold standard for modeling psychostimulant and opioid addiction in animals, but technical limitations have precluded the widespread...

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Bibliographic Details
Main Authors: Lauren M. Slosky, Andrea Pires, Yushi Bai, Nicholas B. Clark, Elizabeth R. Hauser, Joshua D. Gross, Fiona Porkka, Yang Zhou, Xiaoxiao Chen, Vladimir M. Pogorelov, Krisztian Toth, William C. Wetsel, Lawrence S. Barak, Marc G. Caron
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24740-2