Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ‐binding motif of its E6 oncoprotein (HPV18 E6) to degrade its target PSD95/Dlg/ZO‐1...

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Bibliographic Details
Main Authors: Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:FEBS Open Bio
Subjects:
cervical cancer
HPV
invasion
MAGI3
PDZ
Wnt/β‐catenin
Online Access:https://doi.org/10.1002/2211-5463.13298

Internet

https://doi.org/10.1002/2211-5463.13298

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