Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia

Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia

Chronic neutrophilic leukemia (CNL) relates to mutational CSF3R activation with membrane proximal <i>CSF3R</i> mutations such as T618I as driver mutations, but the significance of truncating mutations is not clarified. In CNL, concomitant mutations promote disease progression, but insigh...

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Bibliographic Details
Main Authors: Franziska C. Adam, Jakub Szybinski, Jörg P. Halter, Nathan Cantoni, Friedel Wenzel, Katharina Leonards, Sime Brkic, Jakob R. Passweg, Ivo Touw, Julia E. Maxson, Sara C. Meyer
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Current Oncology
Subjects:
CSF3R
clonal evolution
chronic neutrophilic leukemia
mixed phenotype acute leukemia
Online Access:https://www.mdpi.com/1718-7729/29/2/68

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https://www.mdpi.com/1718-7729/29/2/68

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