Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples

Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples

Genetic analysis of intra-host viral populations provides unique insight into pre-emergent mutations that may contribute to the genotype of future variants. Clinical samples positive for SARS-CoV-2 collected in California during the first months of the pandemic were sequenced to define the dynamics...

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Bibliographic Details
Main Authors: Jeffrey Kimbrel, Joseph Moon, Aram Avila-Herrera, Jose Manuel Martí, James Thissen, Nisha Mulakken, Sarah H. Sandholtz, Tyshawn Ferrell, Chris Daum, Sara Hall, Brent Segelke, Kathryn T. Arrildt, Sharon Messenger, Debra A. Wadford, Crystal Jaing, Jonathan E. Allen, Monica K. Borucki
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
variant
mutation
sequence
quasispecies
iSNV
Online Access:https://www.mdpi.com/1999-4915/14/12/2775

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https://www.mdpi.com/1999-4915/14/12/2775

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