Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis

Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis

Several reports have described a beneficial effect of Mesenchymal Stromal Cells (MSCs) and of their secreted extracellular vesicles (EVs) in mice with experimental colitis. However, the effects of the two treatments have not been thoroughly compared in this model. Here, we compared the effects of MS...

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Bibliographic Details
Main Authors: Anna Maria Tolomeo, Ignazio Castagliuolo, Martina Piccoli, Michele Grassi, Fabio Magarotto, Giada De Lazzari, Ricardo Malvicini, Federico Caicci, Chiara Franzin, Melania Scarpa, Veronica Macchi, Raffaele De Caro, Imerio Angriman, Antonella Viola, Andrea Porzionato, Michela Pozzobon, Maurizio Muraca
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
mesenchymal stromal cells
extracellular vesicles
macrophage polarization
sodium dextran sulfate
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627605/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.627605/full

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