METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells

Summary: METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with METTL3 to mediate N6-methyladenosine (m6A) methylation. Recent studies identified a function for METTL3 in heterochromatin in mouse embryonic stem cells (mESCs), but the molecular function of METTL14 on chromat...

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Bibliographic Details
Main Authors: Mandi Mu, Xinze Li, Li Dong, Jin Wang, Qingqing Cai, Yajun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Yang Shi, Hongjie Shen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006617