Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

Summary: The insulin responsive Akt and FoxO1 signaling axis is a key regulator of the hepatic transcriptional response to nutrient intake. Here, we used global run-on sequencing (GRO-seq) to measure the nascent transcriptional response to fasting and refeeding as well as define the specific role of...

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Bibliographic Details
Main Authors: Dominic Santoleri, Hee-Woong Lim, Matthew J. Emmett, Julian Stoute, Matthew J. Gavin, Jaimarie Sostre-Colón, Kahealani Uehara, Jaclyn E. Welles, Kathy Fange Liu, Mitchell A. Lazar, Paul M. Titchenell
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Physiology
Molecular Physiology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006812

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http://www.sciencedirect.com/science/article/pii/S2589004222006812

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