Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats

Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats

Altered hepatic mitochondrial fatty acid β-oxidation and associated tricarboxylic acid (TCA) cycle activity contributes to lifestyle-related diseases, and circulating biomarkers reflecting these changes could have disease prognostic value. This study aimed to determine hepatic and systemic changes i...

Full description

Bibliographic Details
Main Authors:	Simon Nitter Dankel, Tine-Lise Kalleklev, Siri Lunde Tungland, Marit Hallvardsdotter Stafsnes, Per Bruheim, Thomas Aquinas Aloysius, Carine Lindquist, Jon Skorve, Ottar Kjell Nygård, Lise Madsen, Bodil Bjørndal, Magne Olav Sydnes, Rolf Kristian Berge
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	International Journal of Molecular Sciences
Subjects:	mitochondria liver fatty acid oxidation ketogenesis biomarkers
Online Access:	https://www.mdpi.com/1422-0067/24/21/15536

Similar Items

Dietary-Induced Ketogenesis: Adults Are Not Children
by: Keren Porper, et al.
Published: (2021-09-01)

Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease
by: Raja Gopal Reddy Mooli, et al.
Published: (2022-07-01)

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
by: Shaza Asif, et al.
Published: (2022-07-01)

Association between Impaired Ketogenesis and Metabolic-Associated Fatty Liver Disease
by: Jaehyun Bae, et al.
Published: (2023-10-01)

Impaired ketogenesis is associated with metabolic-associated fatty liver disease in subjects with type 2 diabetes
by: Sejeong Lee, et al.
Published: (2023-02-01)

Bridging Metabolic-Associated Steatotic Liver Disease and Cardiovascular Risk: A Potential Role for Ketogenesis
by: Rafael Suárez del Villar-Carrero, et al.
Published: (2024-03-01)

Intact ketogenesis predicted reduced risk of moderate-severe metabolic-associated fatty liver disease assessed by liver transient elastography in newly diagnosed type 2 diabetes
by: Sejeong Lee, et al.
Published: (2024-01-01)

Punicalagin and Ketogenic Amino Acids Loaded Organic Lipid Carriers Enhance the Bioavailability, Mitochondrial β-Oxidation, and Ketogenesis in Maturing Adipocytes
by: Pandurangan Subash-Babu, et al.
Published: (2022-01-01)

Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based <i>Sofrito</i> in Obese Rats
by: José Fernando Rinaldi de Alvarenga, et al.
Published: (2022-10-01)

PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα
by: Yijun Lin, et al.
Published: (2021-11-01)

In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis—Technical Aspects and Model Interpretation
by: Stanislaw Deja, et al.
Published: (2021-04-01)

Gallic Acid Ameliorated Impaired Lipid Homeostasis in a Mouse Model of High-Fat Diet—and Streptozotocin-Induced NAFLD and Diabetes through Improvement of β-oxidation and Ketogenesis
by: Jung Chao, et al.
Published: (2021-02-01)

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice
by: David B. Stagg, et al.
Published: (2021-11-01)

The Evolution of Ketosis: Potential Impact on Clinical Conditions
by: Latha Nagamani Dilliraj, et al.
Published: (2022-09-01)

The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment
by: Lucas T. Vu, et al.
Published: (2017-06-01)

Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet
by: Daniela Liśkiewicz, et al.
Published: (2021-08-01)

Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia
by: Anuradha Dhingra, et al.
Published: (2021-05-01)

A Look into Liver Mitochondrial Dysfunction as a Hallmark in Progression of Brain Energy Crisis and Development of Neurologic Symptoms in Hepatic Encephalopathy
by: Elena Kosenko, et al.
Published: (2020-07-01)

Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics
by: Julia Stokes, et al.
Published: (2021-07-01)

A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
by: Bodil Bjørndal, et al.
Published: (2015-09-01)

Metabolites and Genes behind Cardiac Metabolic Remodeling in Mice with Type 1 Diabetes Mellitus
by: Tyler N. Kambis, et al.
Published: (2022-01-01)

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney
by: Souad Nasser, et al.
Published: (2022-11-01)

A Japanese case of mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia
by: Tomoko Lee, et al.
Published: (2019-07-01)

Impact of ketogenic diet and ketone diester supplementation on body weight, blood glucose, and ketones in Sprague Dawley rats fed over two weeks
by: LT Claire M. Modica, et al.
Published: (2021-12-01)

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio
by: Rolf K. Berge, et al.
Published: (2020-05-01)

Evaluation of metabolic status of ewes infected with ketosis
by: I. V. Senchuk
Published: (2019-06-01)

The Ketogenic Effect of SGLT-2 Inhibitors—Beneficial or Harmful?
by: Michail Koutentakis, et al.
Published: (2023-11-01)

Ketogenic Diet and Breast Cancer: Recent Findings and Therapeutic Approaches
by: Alfio Giuseppe Urzì, et al.
Published: (2023-10-01)

The Low-Carbohydrate Diet: Short-Term Metabolic Efficacy Versus Longer-Term Limitations
by: Thomas M. Barber, et al.
Published: (2021-04-01)

Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism
by: Corinne Lang, et al.
Published: (2001-01-01)

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients
by: Jan Gunst, et al.
Published: (2021-10-01)

Hepatic metabolite responses to 4-day complete fasting and subsequent refeeding in rats
by: Xiukun Sui, et al.
Published: (2022-09-01)

Sex-Specific Effects on Total Body Fat Gain with 4-Week Daily Dosing of Raspberry Ketone [4-(4-Hydroxyphenyl)-2-butanone] and Ketogenic Diet in Mice
by: Lihong Hao, et al.
Published: (2023-03-01)

The presence of 3-hydroxypropionate and 1,3-propanediol suggests an alternative path for conversion of glycerol to Acetyl-CoA
by: Eunsook S. Jin, et al.
Published: (2021-03-01)

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions
by: Stefan Schuster, et al.
Published: (2012-05-01)

A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats.
by: Carine Lindquist, et al.
Published: (2019-01-01)

Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer’s disease
by: Matin Ramezani, et al.
Published: (2023-11-01)

HMG-CoA Lyase Deficiency: A Retrospective Study of 62 Saudi Patients
by: Majid Alfadhel, et al.
Published: (2022-05-01)

Beta-Hydroxybutyrate: A Dual Function Molecular and Immunological Barrier Function Regulator
by: Jiancheng Qi, et al.
Published: (2022-06-01)

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
by: Jonathan R. Deans, et al.
Published: (2023-12-01)