Pharmacological Inhibition of IKK to Tackle Latency and Hyperinflammation in Chronic HIV-1 Infection

Pharmacological Inhibition of IKK to Tackle Latency and Hyperinflammation in Chronic HIV-1 Infection

HIV latent infection may be associated with disrupted viral RNA sensing, interferon (IFN) signaling, and/or IFN stimulating genes (ISG) activation. Here, we evaluated the use of compounds selectively targeting at the inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex subunits and related kina...

Full description

Bibliographic Details
Main Authors: Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Eva Riveira-Muñoz, Eudald Felip, Lucía Gutiérrez-Chamorro, Ignasi Calba, Marta Massanella, Guillem Sirera, Bonaventura Clotet, Ester Ballana, Roger Badia
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1
latency reversing agents
IKK
TANK binding kinase-1
Online Access:https://www.mdpi.com/1422-0067/23/23/15000

Internet

https://www.mdpi.com/1422-0067/23/23/15000

Similar Items