A Bivalent COVID-19 Vaccine Based on Alpha and Beta Variants Elicits Potent and Broad Immune Responses in Mice against SARS-CoV-2 Variants

A Bivalent COVID-19 Vaccine Based on Alpha and Beta Variants Elicits Potent and Broad Immune Responses in Mice against SARS-CoV-2 Variants

With the emergence and rapid spread of new pandemic variants, especially variants of concern (VOCs), the development of next-generation vaccines with broad-spectrum neutralizing activities is of great importance. In this study, SCTV01C, a clinical stage bivalent vaccine based on trimeric spike extra...

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Bibliographic Details
Main Authors: Rui Wang, Chunyun Sun, Juan Ma, Chulin Yu, Desheng Kong, Meng Chen, Xuejie Liu, Dandan Zhao, Shuman Gao, Shuyuan Kou, Lili Sun, Zeyong Ge, Jun Zhao, Kuokuo Li, Tao Zhang, Yanjing Zhang, Chunxia Luo, Xuefeng Li, Yang Wang, Liangzhi Xie
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Vaccines
Subjects:
bivalent
B.1.351
B.1.1.7
broad-spectrum neutralization
Th1-biased
Online Access:https://www.mdpi.com/2076-393X/10/5/702

Internet

https://www.mdpi.com/2076-393X/10/5/702

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