Fluorescent membrane potential assay for drug screening on Kv10.1 channel: identification of BL-1249 as a channel activator

Fluorescent membrane potential assay for drug screening on Kv10.1 channel: identification of BL-1249 as a channel activator

Resting membrane potential is a bioelectric property of all cells. Multiple players govern this property, the ion channels being the most important. Ion channel dysfunction can affect cells’ resting membrane potential and could be associated with numerous diseases. Therefore, the drug discovery focu...

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Bibliographic Details
Main Authors: Mirsha Aseret Gómez-Herrera, Enikar Patlán, Armando Estrada-Garrido, Arturo Hernández-Cruz, Enoch Luis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
membrane potential
Kv10.1
oncochannel
Kv opener
cell-based fluorescent assay
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1238503/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1238503/full

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