Apolipoprotein E Homozygous ε4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure

Apolipoprotein E Homozygous ε4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure

Theoretical background: The Apolipoprotein E (APOE) ε4 genotype is known to be one of the strongest single-gene predictors for Alzheimer disease, which is characterized by widespread brain structural degeneration progressing along with cognitive impairment. The ε4 allele status has been associated w...

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Main Authors: Janik Goltermann, Ronny Redlich, Katharina Dohm, Dario Zaremba, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Katharina Förster, Susanne Meinert, Verena Enneking, Emily Schlaghecken, Lara Fleischer, Tim Hahn, Harald Kugel, Andreas Jansen, Axel Krug, Katharina Brosch, Igor Nenadic, Simon Schmitt, Frederike Stein, Tina Meller, Dilara Yüksel, Elena Fischer, Marcella Rietschel, Stephanie H. Witt, Andreas J. Forstner, Markus M. Nöthen, Tilo Kircher, Anbupalam Thalamuthu, Bernhard T. Baune, Udo Dannlowski, Nils Opel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neurology
Subjects:
apolipoprotein E
visuospatial working memory
cognitive deficits
hippocampus
structural MRI
Alzheimer
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00552/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00552/full

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