Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells

Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells

Inhibition of the PI3K/Akt/mTOR signaling pathway represents a potential issue for the treatment of cancer, including glioblastoma. As such, rapamycin that inhibits the mechanistic target of rapamycin (mTOR), the downstream effector of this signaling pathway, is of great interest. However, clinical...

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Bibliographic Details
Main Authors: Delphine Séhédic, Loris Roncali, Amel Djoudi, Nela Buchtova, Sylvie Avril, Michel Chérel, Frank Boury, Franck Lacoeuille, François Hindré, Emmanuel Garcion
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
rapamycin
nanoparticles
radiation
hypoxia
mTOR
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.602998/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.602998/full

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