Short Chain Fatty Acids Protect the Cognitive Function of Sepsis Associated Encephalopathy Mice via GPR43

Short Chain Fatty Acids Protect the Cognitive Function of Sepsis Associated Encephalopathy Mice via GPR43

ObjectiveThis study aims to analyze the changes of fecal short chain fatty acids (SCFAs) content and gut microbiota composition in sepsis associated encephalopathy (SAE) mice, further evaluating the effect of SCFAs on cognitive function and the underlying mechanism in SAE mice.MethodsA total of 55 m...

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Bibliographic Details
Main Authors: Hongsen Liao, Haojia Li, Hongguang Bao, Li Jiang, Jiayue Du, Yaoyi Guo, Yanna Si
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neurology
Subjects:
sepsis-associated encephalopathy (SAE)
cecal ligation and puncture (CLP)
short chain fatty acids (SCFAs)
gut microbiota (GM)
cognitive dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.909436/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.909436/full

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