Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy In Vitro and In Vivo

Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy In Vitro and In Vivo

BackgroundColorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC remains a challenge, the development of new strategies gu...

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Bibliographic Details
Main Authors: Pilar M. Lanuza, M. Henar Alonso, Sandra Hidalgo, Iratxe Uranga-Murillo, Sandra García-Mulero, Raquel Arnau, Cristina Santos, Xavier Sanjuan, Llipsy Santiago, Laura Comas, Sergio Redrado, Roberto Pazo-Cid, M. Jose Agustin-Ferrández, Paula Jaime-Sánchez, Cecilia Pesini, Eva M. Gálvez, Ariel Ramírez-Labrada, Maykel Arias, Rebeca Sanz-Pamplona, Julián Pardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
cancer biomarker
NK cell immunotherapy
tumour immune microenvironment
immune checkpoints
HLA-I
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.890836/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.890836/full

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