PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow cytometry approach

PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow cytometry approach

Peripheral immune-checkpoint blockade with mAbs to programmed cell death receptor-1 (PD-1) (either nivolumab or pembrolizumab) or PD-Ligand-1 (PD-L1) (atezolizumab, durvalumab, or avelumab) alone or in combination with doublet chemotherapy represents an expanding treatment strategy for metastatic no...

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Bibliographic Details
Main Authors: Antonella Fameli, Valerio Nardone, Mojtaba Shekarkar Azgomi, Giovanna Bianco, Claudia Gandolfo, Bianca Maria Oliva, Marika Monoriti, Rita Emilena Saladino, Antonella Falzea, Caterina Romeo, Natale Daniele Calandruccio, Domenico Azzarello, Rocco Giannicola, Luigi Pirtoli, Antonio Giordano, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Grazia Cusi, Luciano Mutti, Cirino Botta, Pierpaolo Correale
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
immune checkpoint inhibitors
NSCL
flow cytometry
bioinformatics
NKT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.911579/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.911579/full

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