Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial transcription factor B2 (TFB2M) controls transcriptio...

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Bibliographic Details
Main Authors: Lisa M. Nicholas, Bérengère Valtat, Anya Medina, Lotta Andersson, Mia Abels, Inês G. Mollet, Deepak Jain, Lena Eliasson, Nils Wierup, Malin Fex, Hindrik Mulder
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Molecular Metabolism
Subjects:
Mitochondrial metabolism
Pancreatic β-cells
Insulin secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817302430

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http://www.sciencedirect.com/science/article/pii/S2212877817302430

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