Downregulation of HMGA1 Mediates Autophagy and Inhibits Migration and Invasion in Bladder Cancer via miRNA-221/TP53INP1/p-ERK Axis

Downregulation of HMGA1 Mediates Autophagy and Inhibits Migration and Invasion in Bladder Cancer via miRNA-221/TP53INP1/p-ERK Axis

MicroRNAs (miRNAs) have been implicated in regulating the development and metastasis of human cancers. MiR-221 is reported to be an oncogene in multiple cancers, including bladder cancer (BC). Deregulation of autophagy is associated with multiple human malignant cancers. Whether and how miR-221 regu...

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Bibliographic Details
Main Authors: Xiaoqiang Liu, Zhengtao Zhou, Yibing Wang, Ke Zhu, Wen Deng, Yulei Li, Xiaochen Zhou, Luyao Chen, Yu Li, An Xie, Tao Zeng, Gongxian Wang, Bin Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
high-mobility group AT-hook 1 (HMGA1)
bladder cancer
autophagy
miR-221
TP53INP1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00589/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00589/full

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