Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening

Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the antitumor activity of compounds more accurately, since these models reproduce the tumor microenvironment better.Methods: Here, we report a comparative analysis of cell behavior in the two most widely employed...

Full description

Bibliographic Details
Main Authors: Robson L. F. Amaral, Mariza Miranda, Priscyla D. Marcato, Kamilla Swiech
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Physiology
Subjects:
3D spheroids
RT4 bladder cancer cells
ultra-low attachment plates
hanging-drop plates
drug screening
cytotoxicity assays
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00605/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00605/full

Similar Items