Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

Abstract Background The role of TMEM176A in human hepatocellular carcinoma (HCC) is unknown. This study explored the epigenetic regulation and function of TMEM176A in human HCC. Materials and methods Twelve HCC cell lines and 126 cases of primary cancer were analyzed. Methylation-specific PCR, immun...

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Bibliographic Details
Main Authors: Hongxia Li, Meiying Zhang, Enqiang Linghu, Fuyou Zhou, James G. Herman, Liming Hu, Mingzhou Guo
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Clinical Epigenetics
Subjects:
TMEM176A
DNA methylation
HCC
SAR1A
ERK1/2
Online Access:http://link.springer.com/article/10.1186/s13148-018-0570-4

Internet

http://link.springer.com/article/10.1186/s13148-018-0570-4

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