Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice

Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice

Aims: Oxidative stress and inflammation contribute to atherogenesis. Rac1 GTPase regulates pro-oxidant NADPH oxidase activity, reactive oxygen species (ROS) formation, actin cytoskeleton organization and monocyte adhesion. We investigated the vascular effects of pharmacological inhibition of Rac1 GT...

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Bibliographic Details
Main Authors: Sebastian Zimmer, Philip Roger Goody, Matthias Oelze, Alexander Ghanem, Cornelius F. Mueller, Ulrich Laufs, Andreas Daiber, Felix Jansen, Georg Nickenig, Sven Wassmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
atherosclerosis
endothelial function
oxidative stress
free radicals
Rac1
GTPases
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.680775/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.680775/full

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