Posttranscriptional Regulation of Cyclooxygenase-2 in Rat Intestinal Epithelial Cells

Posttranscriptional Regulation of Cyclooxygenase-2 in Rat Intestinal Epithelial Cells

Modulation of cyclooxygenase-2 (COX-2) mRNA stability plays an important role in the regulation of its expression by oncogenic Ras. Here, we evaluate COX-2 mRNA stability in response to treatment with two known endogenous promoters of gastrointestinal cancer, the bile acid (chenodeoxycholate; CD) an...

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Bibliographic Details
Main Authors: Zhonghua Zhang, Hongmiao Sheng, Jinyi Shao, R. Daniel Beauchamp, Raymond N. DuBois
Format: Article
Language:English
Published: Elsevier 2000-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
cyclooxygenase
gene regulation
stabilization
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800433

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http://www.sciencedirect.com/science/article/pii/S1476558600800433

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