Decreased expression of interferon‐stimulated genes in B cells of patients with chronic hepatitis C during interferon‐free therapy potentially suggests the eradication of hepatitis C virus in the B cells: A cohort study

Decreased expression of interferon‐stimulated genes in B cells of patients with chronic hepatitis C during interferon‐free therapy potentially suggests the eradication of hepatitis C virus in the B cells: A cohort study

Abstract Aims Hepatitis C virus (HCV) infection is monitored by the host innate immunity that includes the endogenous interferon (IFN), which up‐regulates IFN‐stimulated genes (ISGs). HCV is both hepatotropic and lymphotropic, but HCV replication in lymphoid cells is a controversial issue. Here, we...

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Bibliographic Details
Main Authors: Jun Arai, Takayoshi Ito, Yuu Shimozuma, Manabu Uchikoshi, Yoko Nakajima, Masashi Sakaki, Shojiro Uozumi, Atsushi Kajiwara, Ikuya Sugiura, Yumi Otoyama, Hisako Nozawa, Toshikazu Kurihara, Junichi Eguchi, Norihiro Nomura, Dai Sakuma, Masashi Sato, Yoshio Deguchi, Hitoshi Yoshida
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Health Science Reports
Subjects:
anti‐hepatitis C virus DAA (directly acting antivirals)
B cell
hepatitis C virus
interferons
tissue tropism
Online Access:https://doi.org/10.1002/hsr2.176

Internet

https://doi.org/10.1002/hsr2.176

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