Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels

Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels

Current treatments of hepatitis B virus (HBV) are limited to Interferon-alpha or the nucleos(t)ide analogs antiviral therapies, and it is crucial to develop and define new antiviral drugs to cure HBV. In this study, we explored the anti-HBV effect of difluoromethylornithine (DFMO), an irreversibly i...

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Bibliographic Details
Main Authors: Binli Mao, Zhuo Wang, Sidie Pi, Quanxin Long, Ke Chen, Jing Cui, Ailong Huang, Yuan Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
hepatitis B virus
DFMO
ODC1
polyamines
HBc
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00158/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00158/full

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