Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 (KSR2) locus develop severe early-onset obesity and type 2 diabetes. Both conditions are phenocopied in mice with Ksr2...

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Bibliographic Details
Main Authors: Gustavo A Gomez, Charles H Rundle, Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Robert E Lewis, David R Powell, Subburaman Mohan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
adipose tissue
osteoporosis
mouse models
Online Access:https://elifesciences.org/articles/82810

Internet

https://elifesciences.org/articles/82810

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