Macroscopic Dynamic Modeling of Sequential Batch Cultures of Hybridoma Cells: An Experimental Validation

Hybridoma cells are commonly grown for the production of monoclonal antibodies (MAb). For monitoring and control purposes of the bioreactors, dynamic models of the cultures are required. However these models are difficult to infer from the usually limited amount of available experimental data and do...

Full description

Bibliographic Details
Main Authors: Laurent Dewasme, François Côte, Patrice Filee, Anne-Lise Hantson, Alain Vande Wouwer
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Bioengineering
Subjects:
Online Access:http://www.mdpi.com/2306-5354/4/1/17