IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways

Abstract Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP can induce senescence in healthy cells (secondary senescence), modulate immune system function, reshape the extracellular ma...

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Bibliographic Details
Main Authors: Yesuf Siraj, Domenico Aprile, Nicola Alessio, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Senescence
Secretome
SASP
IGFBP
Mesenchymal stromal cells
Online Access:https://doi.org/10.1186/s12964-024-01921-2

Internet

https://doi.org/10.1186/s12964-024-01921-2

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