Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example

Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example

Abstract Background 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to improve future study design and interpretation. Me...

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Bibliographic Details
Main Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:EJNMMI Research
Subjects:
89Zr-immuno-PET
Modelling
Molecular imaging
Monoclonal antibody
Target expression
Online Access:https://doi.org/10.1186/s13550-021-00813-7

Internet

https://doi.org/10.1186/s13550-021-00813-7

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